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These genes, HSPA1A and HSPA1B, are major orchestrators of the cellular stress response and are associated with several human diseases.Our phylogenetic analyses revealed that the duplication of HSPA1A and HSPA1B originated in a lineage proceeding to placental mammals, and henceforth they remained in conserved synteny.

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In contrast to the well-studied evolution of Hsp70s between species, their evolution and natural variation within a species including humans remains almost completely unknown.

Detailed studies using mouse, rat, and human sequences suggested concerted evolution by the gene conversion mechanism.

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